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While the exact location of the neurological injury has yet to be identified since MRI (0.5 T) assessments conducted in 1993 on 2 konzo-affected individuals reported no pathological findings, the phenotypic presentation of various severities (Stages 13) of hyperreflexia and non-spastic paraparesis suggests damage of motor neurons and corresponding brain regions

For weight loss, Semaglutide affects appetite and food intake by interacting with areas of the brain that control hunger and fullness, leading to reduced calorie intake and potential body weight loss over time

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